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Considering that PDCs increased the local concentration of cytotoxic agents in tumor tissues, they can reduce cytotoxic effects to normal tissues and increase therapeutic efficacy

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Experimental evidence has demonstrated that spontaneous neuronal activity in the parietal and frontal neocortex regions of Wistar rats was enhanced, as shown by an increased absolute neuronal discharge frequency

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doi: 10.1016/j.ccell.2016.09.005 110 BluemnEGColemanIMLucasJMColemanRTHernandez-LopezSTharakanRet al